Mar 24, 2015
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New Instagram Account!!!!


Hey All!!! To my disappointment my Instagram account @mrs_angemi was deleted this weekend due to photo reporting. As you all know, I spend countless hours on this blog and on my Instagram account educating others about my life working in the field of pathology as a pathologists’ assistant. Some of the photos I post may be a little upsetting, but this is the reality of the business I am in. I had many followers interested in my photos and my account and it is sad that a few peope are able to ruin it for everyone else, especially since you do not have to follow me on Instagram or subscribe to my blog. I have started a new account because I am moving forward. I will try to redirect my followers to this blog when I have a more graphic photo to post. I would like to thank everyone for their continuted support. My new Instagram account is @mrs_angemi_

Please follow!!!! Lots of great things coming from the iheartautopsy world!! This photo shoot was at our house a few weeks ago for an upcoming article in a UK magazine!

Photo: Jeff Fusco


Jun 24, 2014

My Path to Pathology. Becoming a Pathologists’ Assistant (PA)

I have been receiving a million emails and messages through and my Instagram account @mrs_angemi regarding my education and career. I can not answer all of these individually so I hope this post provides helpful information to those who are interested.

I have a long, extensive, well rounded experience in a medical laboratory setting for a person my age. When I was 19  I was a single mom with a 4 year old, and I knew I had to do something with my life. I enrolled in college with no idea what I wanted to do. I  was fascinated by all things medical, so naturally being a 19 year old female in the United States, I joined college as pre-nursing.

In my first semester I had pre-biology as one of my courses. Let me preface this by saying I dropped out of high school at 16, so I never took a science class more advanced than earth or food science. On my very first day of biology class, my teacher had us looking at some cells under the microscope. I instantly fell in love. I asked my teacher if there was a job out there that I could just sit there and look at cells under the microscope everyday. Luckily my teacher was a Medical Technologist working in microbiology in a local hospital part time. She was very excited to tell me all the jobs available being a microscopist! That was when I got introduced to the medical laboratory.

The next semester I ditched the pre-nursing major and was now a science major with a plan. I fell in love with the microscope and that was going to be my career. Over the next year I was introduced to many different parts of the medical laboratory. The medical laboratory is split into 2 divisions: clinical pathology and anatomic pathology. Clinical pathology consists of of multiple parts such as microbiology, hematology, blood bank, chemistry, etc. Anatomic pathology also consists of multiple parts including cytology, histology, surgical pathology and autopsy- all subjects I love. Right from the start I knew I wanted to go into anatomic pathology, more specifically cytology. Cytology is the study of cells and a job where I could look under the microscope all day. I found out that Thomas Jefferson University in Philadelphia offered a bachelors degree program in cytotechnology. I applied and was accepted. (To read more about what cytology is check out my post “My Old Love: Cytopathology”)

As I was working on my prerequisites, about a year before entering Jefferson, I started working as a microbiology assistant in a hospital which I continued to do throughout my entire time at Jefferson. That job was super cool and I learned so many things about microbiology and the other parts of the lab. I was working at Hahnemann Hospital at the time and the pathology residents would always bring over chunks of organs from autopsy for microbiology studies. I was so curious about autopsies and one day I viewed my first one. Before I went in the morgue I was very scared of the unknown. Even though I was 20 years old, I had never seen a dead body, not even at a funeral. I didn’t know what to expect of how to feel. I walked into the morgue and there was a dead body, 38 year old male, HIV +, who died due to complications of AIDS. The first thought I had when they wheeled the body out of the fridge was OMG this guy is really dead, but I kept my cool because it did not seem to be bothering anyone else there! After I got over the initial shock of being in the same room with a dead person, the rest came easy. Now I will sit down next to a dead body, eat a snack, talk to my friends and its like second nature. I have come a long way!

I graduated Jefferson as a certified cytotechnologist and immediately was hired at Thomas Jefferson University Hospital. By this time I was in love with college and wanted to go for my masters degree. I also really wanted to do autopsies and I found out about this career called a Pathologists’ Assistant. I looked into this degree program but the closest one was in Connecticut or Maryland. Moving was not an option for me because I was a single mom. So I stayed a cytotechnologist for about 2 years.

I was very happy being a cytotechnologist at Jefferson but I wanted more. At that time I was becoming closer to the pathology residents and they were showing me the different parts of anatomical pathology like surgical pathology and autopsy. I was so fascinated by all of it immediately. Just around that time one of the employees of the surgical pathology lab quit, so I asked the director if I could move over there for the same pay and start dissecting specimens and he agreed! Soon after I started in surg path, the Drexel PA program was up and running and within 2 years I had applied and been accepted to the program.

My plan was to work full time as a “PA” while going to PA school full time, which I was able to do because my supervisor at the time was awesome and willing to work with me. As I was working as a PA, before I was certified, I was doing smaller dissections like gallbladders, biopsies, and appendixes and helping with frozen sections. I had a totally different experience than anyone in my PA school class because I had already been working in the lab for years. People always ask me if school was worth it. Absolutely. Trust me I hate making that student loan payment every month, but it definitely formed me into what I am today. Drexel was an excellent program in my opinion and it really brought everything together for me. I will never forget the day a light bulb went off and I said “I get it!” It was just like that, one day I felt like I just understood everything in pathology and what my role was.

Since then I have dissected more than 50,000 surgical pathology specimens as well as performed up to 1000 autopsies. I also teach Drexel students throughout the year as their student mentor and I teach them a course yearly as a review for their board examination through the ASCP (American Society of Clinical Pathology). I have also served time on the board as the Vice Chair and Chair of education for the AAPA (American Association for Pathologists’ Assistants) which I stepped down from because of my crazy life with work and a baby. I also have been volunteering for years for science events around Philadelphia for the Mutter Museum, Franklin Institute and Philadelphia Science Fest.

To learn more about a career as a pathologists’ assistant or PA check out or


Jun 17, 2014

Did You Know Your Organs Can Fall Out!? Organ prolapse.

Hi all! I’m sorry it has been such a long time in between writing! Work, a baby, moving and pure laziness has kept me from it. I have been posting lots of awesome photos with short descriptions which is a sort of “lite” version of this blog. These photos can be seen on the Figure 1 app (username iheartautopsy) or Instagram app (username @mrs_angemi). Also, I am working on a post describing in detail my work history in the laboratory and becoming a Pathologists’ Assistant. I am receiving so many emails and messages regarding my education and I can’t keep up! Hopefully this post will be helpful! Thank you for your continued interest and support. I have some very cool posts coming up!

All of the organs in the human body are held in place by muscles, ligaments and surrounding organs. They are designed to function properly when they are in place. They are also designed to function when the body undergoes certain conditions such as pregnancy. Unfortunately pregnancy and a vaginal childbirth can be responsible for organ prolapse. Organ prolapse can also occur in any age in both men and woman. Other causes of organ prolapse include previous pelvic surgeries, constipation, infections, straining during bowel movements and weakness of the bowel muscles  due to age. The most common organs to prolapse are the uterus, bladder and rectum.

The pelvic organs are held tightly in place by the muscles of the pelvic floor and perineum. When these muscles get damaged, the organs begin to slip out of place and eventually fall out.

Uterine Prolapse

Here is an illustration of a prolapsed uterus compared to the normal female anatomy. As you can see, as the uterus begins to slip out of place it begins to protrude into the vagina.

prolapse uteus

Woman of perimenopausal age are at most risk for uterine prolapse, but it can happen at any age. The decrease of estrogen can be a contributor. When the pelvic muscles are weakened, the uterus can begin to slip into the vagina. The severity varies from person to person. If the prolapse is mild, it may cause no symptoms. A more severe case would present with symptoms such as pressure, heaviness or pulling of the vagina, low back pain, sexual problems including loss of vaginal tone, and tissue protruding into the vagina.

This is a clinical example of 2 severe forms of uterine prolapse showing the uterus protruding through the vagina. This severity would be difficult to repair with any other method but surgery.

uter pro clin uterine prolapse clinical

With less severe cases of prolapse, treatment options include a vaginal pessary.  This device fits inside the vagina and holds the uterus in place. This can be used as a temporary or permanent treatment. They come in many shapes and sizes, so the doctor will measure and fit each patient for the proper device. Vaginal pessaries can irritate vaginal tissues causing sores ulcerations. They may also interfere with sexual intercourse.



Sometimes when the uterus begins to prolapse and fall out of place, other organs surrounding the uterus and vagina come along for the ride. This most commonly occurs with the bladder and rectum.


Cystocele refers to the bladder prolapsing into the vaginal canal. This commonly occurs with uterine prolapse because the pelvic muscles are so weak when the uterus begins to fall out it pulls the bladder along with it. It can also happen without uterine prolapse. This has the same symptoms of uterine prolapse. The patient may also having a feeling that the bladder is not emptied completely or recurrent bladder infections. Mild prolapse will cause no symptoms. A vaginal pessary can also be used to repair mild cases of this, if surgery is needed, the bladder will be pushed back into place and the extra stretched tissue will be removed.


Here is a clinical photo showing the bladder protruding into the vagina.



Rectocele refers to the rectum prolapsing into the vaginal canal. This also commonly occurs with uterine prolapse because the pelvic muscles are so weak when the uterus begins to fall out it pulls the rectum along with it. It can also happen without uterine prolapse. Constipation, straining during bowel movements and heavy lifting contribute to this. This has the same symptoms of uterine prolapse. The patient may also having a feeling that the rectum is full or difficulty making a bowel movement.  Mild prolapse will cause no symptoms. A vaginal pessary can also be used to repair mild cases of this, if surgery is needed, the bowel will be pushed back into place, but unfortunately the bowel function may not improve.


Here is a clinical photo showing the rectum protruding into the vagina.


Rectal Prolapse

There are 2 types of external rectal prolapse, partial prolapse (also called mucosal prolapse) is when the lining of the rectum slides out of place and usually sticks out of the anus. This can happen straining during a bowel movement and is most common in children younger than 2 years. Complete prolapse is when the entire wall of the rectum slides out of place and usually sticks out of the anus. At first, this may occur only during bowel movements. Eventually, it it can occur when standing and walking and in severe cases it sticks out all the time.

Here is an illustration showing the normal place of the rectum and a rectum with prolapse.

rectal pro image


Many things increase the chance of developing rectal prolapse in children including cystic fibrosis, anus surgery as an infant, malnutrition, deformities of the bowel, straining during bowel movements and infections.

Here is a clinical photo of a child with rectal prolapse.


An infection common in children that causes rectal prolapse is a whipworm infection. This is not common in the western world. Trichuriasis also known as whipworm infection is an infection by the parasitic worm Trichuris trichiura. Whipworms live in the large intestine and whipworm eggs are passed in the feces of infected persons. If the infected person defecates outside  or if human feces as used as fertilizer, eggs are deposited on soil. They can then mature into a form that is infective. Whipworm infection is caused by ingesting eggs. This can happen when hands or fingers that have contaminated dirt on them are put in the mouth or by consuming vegetables or fruits that have not been carefully cooked, washed or peeled. People with heavy symptoms can experience frequent, painful passage of stool that contains a mixture of mucus, water, and blood. Rectal prolapse can also occur. Children with heavy infections can become severely anemic and growth-retarded. Whipworm infections are treatable with medication.

Here is a clinical photo showing a whipworm infection in rectal prolapse.


Here is a clinical photo of complete rectal prolapse in an adult.

rectal pro clinicalrectal prolapd clinical

If the choice is made to do surgery, like in a severe case of prolapse seen above, a segment of the rectum or rectosigmoid colon will be removed and sent to us in pathology. This is what the specimen looks like. Here you can see the end of the colon which is the rectum that was sticking out of the patient. These specimens are not complex, we basically just look at it to confirm prolapse. One section I always tell residents and PA students to exam is perpendicular sections of the prolapse. Sometimes with long standing prolapse, metaplasia of the rectum lining can occur changing the cells from glandular to squamous because it is exposed and gets irritated. This metaplasia can be seen microscopically.

rectal prolapse gross

New Instagram, Same Great Photos!

Hi all! I know many of you have noticed my Instagram account @mrsangemi was deleted yesterday. This is now the second time IG has deleted my account due to users reporting my educational photos. I am hoping the 3rd time is a charm so I created a new account @mrs_angemi. I am making this account private in the hopes that only people who are truly interested in my photos will follow me. I left Instagram with over 14K followers and I am hoping the majority of them can find me again. My husband told me that you only have haters when you are doing something right, and I think he is on to something. Hopefully those people will not ruin it for the rest of you who enjoy my feed. Thank you for the continued support. I have a ton of ideas and I promise I will be writing some new posts here on soon!


Disclaimer. All materials posted on my website are intended to showcase my love of pathology and art and the correlation between the two. In no way am I trying to exploit any patients or their specimens. All images and information should be used to educated people in the pathology field and enlighten others into my profession. Enjoy.